Sell Isoliquiritigenin
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Sell Isoliquiritigenin
Product Name Isoliquiritigenin
Latin Name Isoliquiritigenin
Molecular Formula C15H12O4
Molecular Weight 256
CAS NO 961-29-5
Appearance White powder
Product Content ≥98%
Analytical Method HPLC
Product Origin Glycyrrhiza uralensis Fisch.; Glycyrrhiza inflata Bat.; Glycyrrhiza glabra L.
Action and Uses Isoliquiritigenin is a natural flavonoid isolated from licorice, shallot and bean sprouts. The effect of isoliquiritigenin on cell proliferation and cell cycle progression was examined in the A549 human lung cancer cell line. Isoliquiritigenin significantly inhibited the proliferation of lung cancer cells in a dose- and time-dependent manner. Flow cytometric analysis demonstrated that isoliquiritigenin restrained the cell cycle progression at G2/M phase. Further examinations using cDNA arrays and real-time quantitative RT-PCR revealed that isoliquiritigenin enhanced the expression of p21CIP1/WAF1, a universal inhibitor of cyclin-dependent kinases. These results suggest that isoliquiritigenin will be a promising agent for use in chemopreventive or therapeutics against lung cancer.
Latin Name Isoliquiritigenin
Molecular Formula C15H12O4
Molecular Weight 256
CAS NO 961-29-5
Appearance White powder
Product Content ≥98%
Analytical Method HPLC
Product Origin Glycyrrhiza uralensis Fisch.; Glycyrrhiza inflata Bat.; Glycyrrhiza glabra L.
Action and Uses Isoliquiritigenin is a natural flavonoid isolated from licorice, shallot and bean sprouts. The effect of isoliquiritigenin on cell proliferation and cell cycle progression was examined in the A549 human lung cancer cell line. Isoliquiritigenin significantly inhibited the proliferation of lung cancer cells in a dose- and time-dependent manner. Flow cytometric analysis demonstrated that isoliquiritigenin restrained the cell cycle progression at G2/M phase. Further examinations using cDNA arrays and real-time quantitative RT-PCR revealed that isoliquiritigenin enhanced the expression of p21CIP1/WAF1, a universal inhibitor of cyclin-dependent kinases. These results suggest that isoliquiritigenin will be a promising agent for use in chemopreventive or therapeutics against lung cancer.
- Place of Origin:
- China
- Brand:
- Shaanxi Green
- Packing:
- 1kg per bag
- Payment Terms:
- ;T/T
- Delivery Time:
- 5
- Min Order Quantity:
- 1KG